A perfect square is a number times itself, so in its prime factorization every prime must appear an even number of times (the two equal copies split the primes evenly). Check 22×34: two 2s and four 3s, both even, so the primes pair into two identical groups.
22×34=(2×3×3)×(2×3×3)=18×18=324
Every exponent is even. Each of the others has a prime with an odd exponent (a leftover that cannot be paired), so they are not perfect squares.