Three powers are missing, so the top row is 1,0,0,0,−16 with corner 2. Bring down the 1; then each step doubles and adds: 0+2=2, 0+4=4, 0+8=8, and finally −16+16=0.
211022044088−16160
The quotient is x3+2x2+4x+8 with remainder 0. Dividing by x+2 instead would give the sign-alternating quotient x3−2x2+4x−8.