Raising to a positive power preserves order among positive numbers, so raise all four to the 12th power (the common multiple of the denominators) and compare the results.
(21/2)12=26=64,(31/3)12=34=81,(81/4)12=83=512,(61/6)12=62=36
The largest twelfth power belongs to the largest number, so 81/4 wins.