For x2+4x+1 you need two integers with product 1 and sum 4, but the only integer pairs multiplying to 1 are 1,1 and −1,−1, with sums 2 and −2.
no integer pair has product 1 and sum 4
So it is irreducible. The others factor as (x+2)2, (x+1)(x+3), and (x+1)(x+4).